Goodman & Gilman's Pharmacology > Chapter 31. Treatment of Myocardial Ischemia >
Mechanopharmacological Therapy: Drug-Eluting Endovascular Stents
... currently being used in intravascular stents: paclitaxel ( TAXOL ) and sirolimus ( RAPAMYCIN ). Paclitaxel is a tricyclic diterpene that inhibits cellular proliferation by binding ...

Goodman & Gilman's Pharmacology > Chapter 51. Antineoplastic Agents > Antimitotic Drugs > Taxanes >
Absorption, Fate, and Excretion
... Paclitaxel is administered as a 3-hour infusion of 135 to 175 mg/m 2 every 3 weeks, or as a weekly 1-hour infusion of 80 to 100 mg/m 2 . Longer infusions (96 hours) have yielded significant ...

Goodman & Gilman's Pharmacology > Chapter 51. Antineoplastic Agents > Antimitotic Drugs > Taxanes >
Chemistry
... Paclitaxel is a diterpenoid compound that contains a complex 8-member taxane ring as its nucleus (Figure 51–14). The side chain linked to the taxane ring at C13 is essential for its ...

Goodman & Gilman's Pharmacology > Chapter 51. Antineoplastic Agents > Antimitotic Drugs > Taxanes >
Clinical Toxicities
... Paclitaxel exerts its primary toxic effects on the bone marrow. Neutropenia usually occurs 8 to 11 days after a dose and reverses rapidly by days 15 to 21. Used with filgrastim ...

Goodman & Gilman's Pharmacology > Chapter 51. Antineoplastic Agents > Antimitotic Drugs > Taxanes >
Mechanism of Action
... Interest in paclitaxel was stimulated by the finding that the drug possessed the unique ability to promote microtubule formation at cold temperatures and in the absence of GTP. It binds ...

Goodman & Gilman's Pharmacology > Chapter 51. Antineoplastic Agents > Antimitotic Drugs > Taxanes >
Therapeutic Uses
... Docetaxel and paclitaxel have become central components of regimens for treating metastatic ovarian, breast, lung, and head and neck cancers (McGuire et al., 1996; Seidman, 1998). Docetaxel ...

Principles of Critical Care > Chapter 74. Toxicities of Chemotherapy > Cardiovascular Toxicity > Electrocardiographic Changes and Arrhythmias >
Paclitaxel^{27, 28}
... Paclitaxel 27, 28 Paclitaxel causes asymptomatic, reversible sinus bradycardia, with heart rates ranging from 30 to 50 beats per minute, in up to 29% of patients during a 24-hour ...

Goodman & Gilman's Pharmacology > Chapter 51. Antineoplastic Agents > Antineoplastic Agents: Introduction >
Table 51–1 Chemotherapeutic Agents Useful in Neoplastic Disease
 
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Goodman & Gilman's Pharmacology > Appendix II. Design and Optimization of Dosage Regimens: Pharmacokinetic Data > Design and Optimization of Dosage Regimens: Pharmacokinetic Data: Introduction >
Table A–II–9 Pharmacokinetic Data: P–Q Drugs
 
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