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Hadzic's Peripheral Nerve Blocks and Anatomy for Ultrasound-Guided Regional Anesthesia, 2e
Section 1. Foundations of Peripheral Nerve Blocks
Chapter 2. Local Anesthetics: Clinical Pharmacology and Rational Selection
Local Anesthetics: Clinical Pharmacology and Rational Selection: Introduction
anesthesia, nerve block; anesthetics, local; nerve block.
Local anesthetics (LAs) prevent or relieve pain by interrupting nerve conduction. They bind to specific receptor sites on the sodium (Na
) channels in nerves and block the movement of ions through these pores. Both the chemical and pharmacologic properties of individual LA drugs determine their clinical properties. This chapter discusses the basics of the mechanism of action of LAs, their clinical use, and systemic toxicity prevention and treatment...."
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